Posts Tagged ‘Alzheimer’s Disease’

Gingko Biloba NOT Associated with Risk of Bleeding

Thursday, May 12th, 2011

For years, doctors have been warning of a possible bleeding side effect of ginko biloba, an flavonoid and terpenoid antioxidant herb that has been found to have many beneficial effects in the body.

Some doctors worried about drug interactions with specific medications, have warned a patient not to use ginko biloba due to an increased risk of bleeding. This warning is normally reserved for NSAIDs, like ibuprofen and aspirin. However, doctors started lumping in gingko biloba with NSAIDs, as causing a potential bleeding interaction.

Although such concerns are very rare, sometimes doctors warn patients about possible side effects of gingko biloba used in combination with anticonvulsive drugs, SSRI antidepressants, and immunosuppressive drugs. However, such concerns are so rare that there may be only one or two case reports …which do not necessarily show a cause and effect of using gingko biloba and the medical concern. For example, Serotonin Syndrome can happen with any SSRI with or without gingko biloba. The fact that a person who experienced Serotonin Syndrome and happen to also be taking gingko biloba does not show a cause and effect. Why blame the gingko biloba, when it was the SSRI could cause this serious problem on its own?

In either case, we can cross the biggest concern that doctors have had about gingko biloba off the list, that of increasing the risk of bleeding.

This month (May 2011), a systematic review and meta-analysis of randomized controlled studies found that there is NOT an associated risk of bleeding with standardized ginko biloba extract. Andrea J Kellermann and Charlotte Kloft (2011). Is There a Risk of Bleeding Associated with Standardized Ginkgo biloba Extract Therapy? A Systematic Review and Meta-analysis. Pharmacotherapy: Volume 31, Issue 5, pp. 490-502. (See reference link below.)

People can continue to use ginko biloba extract for many reasons, and now do so without the worry of abnormal bleeding; nor worry about drug interactions that are normally a concern with aspirin and other NSAIDs.

Eighteen randomized controlled studies involving a total of 1,985 adults were enrolled to receive either ginko biloba exract (GBE) or placebo; 87% were patients with dementia, peripheral artery disease, or diabetes mellitus; 13% were healthy volunteers. Based on meta-analysis of hemostasis outcomes, comparison of mean difference or baseline change between treatment and placebo groups did not indicate a higher bleeding risk associated with standardized GBE. (See reference below.)

In other words, ginko biloba extract does not increase the risk of bleeding problems as do NSAIDs.

Gingko biloba extract is often used alone, or even better, in conjunction with other nutritional supplements such as vitamin E, vitamin C, fish oil, grape seed extract, resveratrol, co-enzyme Q10, olive extract, tumeric extract, and many others, for multiple purposes. A partial list of some of these conditions that antioxidants such as gingko biloba extract and others have been shown to provide benefits are:

Memory
Mood
PMS
Menopause
Macular Degeneration
Glaucoma
Dementia in Alzheimer’s Disease
NON-Alzheimer’s Dementia
Claudication
Mutliple Scelerosis
Tinnitus

Read More: http://pharmacotherapyjournal.org/doi/abs/10.1592/phco.31.5.490

Grape Seed Extract Prevents and Arrests Cancer

Thursday, January 22nd, 2009

In past and recent studies, grape seed extract was shown to stop the growth of human colorectal cancer cells AND cause colorectal cancer cells to undergo apoptosis, …self destruction. Furthermore, recent studies have given further evidence that grape seed extract also inhibits breast cancer, oral cancer, and prostate cancer.  It has been shown to inhibit angiogenesis (growth of blood vessels feeding cancer cells) in breast cancer cells, and most likely works similarly in all types of cancers. Research continues to show evidence that grape seed extract is both safe and effective in the prevention of many types of cancers, induce self-induced destruction (apoptosis) of cancer once present, reduce the risk of arterial plaque formation, maintain heart health, reduce inflammation in all areas of the body (including helping arthritis, fibromyalgia, migraine headaches, asthma and allergies, and provide numerous other health benefits, including crossing the blood-brain barrier and reduce damage and aging of brain cells (which would then may slow or prevent dementia). The extent of the benefits of grape seed extract alone is absolutely astounding.

Since 1995, in my medical practice I recommended grape seed extract (in addition to a broad spectrum multi-antioxidant, chelated mineral formulation, and fish oil) to my patients as a way to boost the immune system, and decrease the risk of heart disease, cancer, type 2 diabetes, inflammatory diseases, multiple sclerosis, autoimmune diseases, and many other medical maladies. The results I personally witnessed was so impressive that I learned to recommend even higher doses of grape seed extract, on the order of 360 to 720 mg per day (for more severe cases).

Recent References (scores more are available): 

Kaur M, Mandair R, Agarwal R, Agarwal C.   Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.   Nutr Cancer. 2008;60 Suppl 1:2-11.

Leifert WR, Abeywardena MY.   Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.  Nutr Res. 2008 Dec;28(12):842-50. Epub 2008 Nov 8.

Engelbrecht AM, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K.   Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line.   Cancer Lett. 2007 Dec 8;258(1):144-53. Epub 2007 Oct 17.

Lu J, Zhang K, Chen S, Wen W.  Grape seed extract inhibits VEGF expression via reducing HIF-1{alpha} protein expression.  Carcinogenesis. 2009 Jan 8. [Epub ahead of print]

Wen W, Lu J, Zhang K, Chen S.  Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway.  Cancer Prev Res (Phila Pa). 2008 Dec;1(7):554-61.

Ramchandani AG, Karibasappa GS, Pakhale SS.  Antitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapes.  J Environ Pathol Toxicol Oncol. 2008;27(4):321-31.

Huang TT, Shang XJ, Yao GH, Ge JP, Teng WH, Sun Y, Huang YF.  [Grape seed extract inhibits the growth of prostate cancer PC-3 cells]  Zhonghua Nan Ke Xue. 2008 Apr;14(4):331-3.

Chatelain K, Phippen S, McCabe J, Teeters CA, O’Malley S, Kingsley K.  Cranberry and Grape Seed Extracts Inhibit the Proliferative Phenotype of Oral Squamous Cell Carcinomas.  Evid Based Complement Alternat Med. 2008 Jul 23. [Epub ahead of print]