Posts Tagged ‘breast cancer’

Grape Seed Extract Prevents and Arrests Cancer

Thursday, January 22nd, 2009

In past and recent studies, grape seed extract was shown to stop the growth of human colorectal cancer cells AND cause colorectal cancer cells to undergo apoptosis, …self destruction. Furthermore, recent studies have given further evidence that grape seed extract also inhibits breast cancer, oral cancer, and prostate cancer.  It has been shown to inhibit angiogenesis (growth of blood vessels feeding cancer cells) in breast cancer cells, and most likely works similarly in all types of cancers. Research continues to show evidence that grape seed extract is both safe and effective in the prevention of many types of cancers, induce self-induced destruction (apoptosis) of cancer once present, reduce the risk of arterial plaque formation, maintain heart health, reduce inflammation in all areas of the body (including helping arthritis, fibromyalgia, migraine headaches, asthma and allergies, and provide numerous other health benefits, including crossing the blood-brain barrier and reduce damage and aging of brain cells (which would then may slow or prevent dementia). The extent of the benefits of grape seed extract alone is absolutely astounding.

Since 1995, in my medical practice I recommended grape seed extract (in addition to a broad spectrum multi-antioxidant, chelated mineral formulation, and fish oil) to my patients as a way to boost the immune system, and decrease the risk of heart disease, cancer, type 2 diabetes, inflammatory diseases, multiple sclerosis, autoimmune diseases, and many other medical maladies. The results I personally witnessed was so impressive that I learned to recommend even higher doses of grape seed extract, on the order of 360 to 720 mg per day (for more severe cases).

Recent References (scores more are available): 

Kaur M, Mandair R, Agarwal R, Agarwal C.   Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.   Nutr Cancer. 2008;60 Suppl 1:2-11.

Leifert WR, Abeywardena MY.   Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.  Nutr Res. 2008 Dec;28(12):842-50. Epub 2008 Nov 8.

Engelbrecht AM, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K.   Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line.   Cancer Lett. 2007 Dec 8;258(1):144-53. Epub 2007 Oct 17.

Lu J, Zhang K, Chen S, Wen W.  Grape seed extract inhibits VEGF expression via reducing HIF-1{alpha} protein expression.  Carcinogenesis. 2009 Jan 8. [Epub ahead of print]

Wen W, Lu J, Zhang K, Chen S.  Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway.  Cancer Prev Res (Phila Pa). 2008 Dec;1(7):554-61.

Ramchandani AG, Karibasappa GS, Pakhale SS.  Antitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapes.  J Environ Pathol Toxicol Oncol. 2008;27(4):321-31.

Huang TT, Shang XJ, Yao GH, Ge JP, Teng WH, Sun Y, Huang YF.  [Grape seed extract inhibits the growth of prostate cancer PC-3 cells]  Zhonghua Nan Ke Xue. 2008 Apr;14(4):331-3.

Chatelain K, Phippen S, McCabe J, Teeters CA, O’Malley S, Kingsley K.  Cranberry and Grape Seed Extracts Inhibit the Proliferative Phenotype of Oral Squamous Cell Carcinomas.  Evid Based Complement Alternat Med. 2008 Jul 23. [Epub ahead of print]

Soy vs. Whey Protein: Confused Over Which One is Better?

Wednesday, December 10th, 2008

Although I get asked, “Which is better, soy or whey protein?” …my question back is, “Better for what?” Each one is an excellent sources of protein, and each one has its own benefits.  I suggest to use at least both sources of protein in order to obtain the benefits each provide.  We need to consume protein in order to make and replace protein; and athletes and body-builders are very familiar with whey protein as an excellent source of “bio-available” protein.

Protein is essential for producing antibodies, hormones, new muscle tissue, and the oxygen-carrying protein in blood, hemoglobin. All protein lost or destroyed within the body must be replaced by bio-available protein in order for new tissue to be constructed.

Our bodies are able to manufacture many of the amino acids that are used to produce protein; however, there are nine “essential” amino acids that we cannot manufacture, but must obtain from the protein in our food. Not all protein sources provide these essential amino acids. For example, whey is an excellent source of glutathione and the branched chain essential amino acids L-leucine, L-valine and L-isoleucine.

The protein in most beans and vegetables may contain all the essential amino acids, but they are not naturally concentrated in foods, and thus vegans often do not readily obtain adequate amounts of protein, particularly the branch-chained amino acids. However, this can be compensated for by consuming concentrated protein sources, such as found within quality meal-replacement drinks.

Almost daily, I drink one or two nutritious meal-replacement drinks. These drinks not only contain a blend of both soy and whey proteins, they also contain protein from two additional sources, that of rice and pea. By obtaining a blend of proteins from these four sources one is obtaining all the essential amino acids and the benefits that each provide.

Soybeans contain high amounts of protein. Soy protein and soy isoflavones have been found to help reduce the symptoms of menopause, help reduce the risk of osteoporosis, and to help prevent a number of hormone-related diseases, such as endometrial cancer, breast cancer, and prostate cancer. (Neither soy nor soy isoflavones increase the risk of breast cancer; in fact quite the opposite, they help maintain breast health.)

In addition, soy has been observed to help maintain heart health. Even the Food and Drug Administration (FDA) has stated 25 grams of soy protein per day can reduce the chances of developing heart disease.

Soy protein has also been shown to help the thyroid, which can help with obtaining a leaner body. In the case of a soy allergy, the opposite would be true …reduced metabolism and weight gain.

If you are not allergic to soy, there are very few side effects to including soy in your diet. The most common side-effect of soy is the production of intestinal gas. Flatulence is a common side-effect of all beans (including soy), due to the bowel bacteria’s fermenting effect on the indigestible sugars contained within beans. Humans do not have the enzyme alpha-galactosidase necessary to break down the sugars that the bowel bacteria feast upon and produce gas.

Beano, purchased over-the-counter, contains alpha galactosidase, and regular use may be able to reduce gas production by breaking down the oligosaccharides (bean sugars) before the bacteria in the large bowel has a chance to ferment the sugar.

For those who are allergic to soy, gas would not be the only problem present, but significant diarrhea and abdominal bloating, hives, skin rash, and worst case, breathing problems. Soy isoflavones are not the same as pure soy protein; and even if one is allergic to soy it wound not mean they were allergic to soy isoflavones, as soy protein (the allergen of the allergy) is not found in soy isoflavones.

Whey protein is used by athletes and body builders because of the higher level of essential amino acids, particularly the branched chain amino acids that are metabolized in the muscle not the liver. Protein is critical in repairing not only muscle, but many other body tissues. Whey is helpful for weight loss and building muscle in those who work out, but will do little to help build muscle in those with sedentary lifestyles.

Whey protein affects the digestive tract in much the same way as yogurt. Therefore, it is considered to be a natural remedy for many intestinal issues. In fact, it is often used in Sweden to help prevent bowel problems, gas, and constipation. However, since whey is obtained from a dairy source (it is the liquid by-product of curdled milk … the solid becomes cheese, and the liquid protein part is dried as a source for whey). Therefore, those who are lactose intolerant should avoid whey protein, and steer towards soy protein only, as gas, constipation, and bloating can be significant. Over-the-counter Lactaid is available to help provide the enzyme necessary to break down dairy-derived lactose sugar found in whey products.

Since both soy and whey protein may lead to constipation, it is important to find a meal-replacement drink that provides adequate fiber to overcome this side-effect.

Whey protein makes a good alternative to those who are allergic to soy, and vice-versa, but the blend of soy and whey will render the user with the benefits of each, particularly if blended with adequate fiber, as mentioned. While companies selling protein supplements tout the benefits of whatever they’re selling as “the best,” whether it is soy, whey, or a combination of rice and pea protein, which together the last two alone hit numbers between 85 to 90% bioavailable protein, it is good to know that at least one company was wise enough to combine all four protein sources in their meal-replacement drinks, along with fiber, low-glycemic sugar, and vitamins and minerals.  The balance is its greatest strength as a perfect meal replacement.

A summary of the benefits of Soy and Whey Proteins, and that you can have BOTH:

Soy Protein

  • Soy protein has been found to be higher in non-essential amino
  • The consumption of 25-50 grams of soy protein daily may enhance production of thyroid stimulation hormones that regulate the metabolic rate, thereby making it easier for us to lose both body weight and fat and create a leaner body.
  • Soy is good for athletes: in a study from Romania endurance athletes experienced lean body mass, increased strength, and decrease fatigue while training. (Revue Roumaine de Physiologie 29, 3-4:63-70, 1992)
  • It contains more protein by weight than beef, fish or chicken, and contains less fat (especially saturated fat than meat).
  • The FDA has approved the following statement: ”Diets low in saturated fat and cholesterol that include 25 grams of soy protein a day may reduce the risk of heart disease.”
  • Other studies show that soy protein isolate has the ability to effectively lower LDL cholesterol and triglyceride levels in the blood
  • Soy may improve kidney functioning
  •  
    Whey Protein

  • Whey protein assists in losing excess weight and maintaining optimal weight
  • Whey protein, combined with resistance training, even those who have immunosuppressive disorders (AIDS) can increase body cell mass, muscle mass and muscle strength, according to a study in AIDS (15, 18:2431-40, 2001).
  • Whey protein is superior to other proteins when it comes to anabolic response. It has consistently been shown to stimulate the anabolic hormones after a workout. In other words, whey protein improves athletic performance.
  • It mixes well and is low in fat and lactose, and has a superior amino acid profile
  • Whey protein lacks no essential amino acids. It needs no fortification or additive to make it complete. It is complete in its natural form
  • Whey enhances the immune system because it raises glutathione levels. Glutathione is a powerful antioxidant that helps our immune cells stay charged to help ward off cancer, bacterial infection and viruses. In other words, it helps improve the immune system.
  • Whey is also very high in glutamine and the branch chain amino acids L-leucine, L-valine and L-isoleucine, important aminos for repairing muscle
  • Whey acts as a natural antibacterial or anti-viral
  • Whey reduces the symptoms of Chronic Fatigue Syndrome
  • Whey reduces liver damage
  • Whey improves blood pressure
  • Whey improves the function of the digestive system
  • Whey reduces gastric mucosal injury seen in ulcerative colitis