Posts Tagged ‘Diabetes’

Grape Seed Extract Prevents and Arrests Cancer

Thursday, January 22nd, 2009

In past and recent studies, grape seed extract was shown to stop the growth of human colorectal cancer cells AND cause colorectal cancer cells to undergo apoptosis, …self destruction. Furthermore, recent studies have given further evidence that grape seed extract also inhibits breast cancer, oral cancer, and prostate cancer.  It has been shown to inhibit angiogenesis (growth of blood vessels feeding cancer cells) in breast cancer cells, and most likely works similarly in all types of cancers. Research continues to show evidence that grape seed extract is both safe and effective in the prevention of many types of cancers, induce self-induced destruction (apoptosis) of cancer once present, reduce the risk of arterial plaque formation, maintain heart health, reduce inflammation in all areas of the body (including helping arthritis, fibromyalgia, migraine headaches, asthma and allergies, and provide numerous other health benefits, including crossing the blood-brain barrier and reduce damage and aging of brain cells (which would then may slow or prevent dementia). The extent of the benefits of grape seed extract alone is absolutely astounding.

Since 1995, in my medical practice I recommended grape seed extract (in addition to a broad spectrum multi-antioxidant, chelated mineral formulation, and fish oil) to my patients as a way to boost the immune system, and decrease the risk of heart disease, cancer, type 2 diabetes, inflammatory diseases, multiple sclerosis, autoimmune diseases, and many other medical maladies. The results I personally witnessed was so impressive that I learned to recommend even higher doses of grape seed extract, on the order of 360 to 720 mg per day (for more severe cases).

Recent References (scores more are available): 

Kaur M, Mandair R, Agarwal R, Agarwal C.   Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.   Nutr Cancer. 2008;60 Suppl 1:2-11.

Leifert WR, Abeywardena MY.   Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.  Nutr Res. 2008 Dec;28(12):842-50. Epub 2008 Nov 8.

Engelbrecht AM, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K.   Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line.   Cancer Lett. 2007 Dec 8;258(1):144-53. Epub 2007 Oct 17.

Lu J, Zhang K, Chen S, Wen W.  Grape seed extract inhibits VEGF expression via reducing HIF-1{alpha} protein expression.  Carcinogenesis. 2009 Jan 8. [Epub ahead of print]

Wen W, Lu J, Zhang K, Chen S.  Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway.  Cancer Prev Res (Phila Pa). 2008 Dec;1(7):554-61.

Ramchandani AG, Karibasappa GS, Pakhale SS.  Antitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapes.  J Environ Pathol Toxicol Oncol. 2008;27(4):321-31.

Huang TT, Shang XJ, Yao GH, Ge JP, Teng WH, Sun Y, Huang YF.  [Grape seed extract inhibits the growth of prostate cancer PC-3 cells]  Zhonghua Nan Ke Xue. 2008 Apr;14(4):331-3.

Chatelain K, Phippen S, McCabe J, Teeters CA, O’Malley S, Kingsley K.  Cranberry and Grape Seed Extracts Inhibit the Proliferative Phenotype of Oral Squamous Cell Carcinomas.  Evid Based Complement Alternat Med. 2008 Jul 23. [Epub ahead of print]